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SIGNET MEDICAL SOLUTIONS, INC. 

(A Subsidiary of Signet International Holdings, Inc. OTC: SIGN)

Signet Appoints M. Thomas Boyer Consultant
For the ConnREAP™, New Medical Device Prevents Amputations

 

Aurora, CO, February 26, 2019. Tom Donaldson, President of Signet International Holdings, Inc. (OTC:SIGN) announced today the appointment of M. Thomas Boyer, V/P, to assume a consulting role in the development of the new medical device, ConnREAP™. “I am pleased that Tom has accepted our offer to help us not only to characterize this incredible device, but to also represent Signet to medical academia. With more than 25 years as a health care leader, and after years of working with Dr. Conn, Tom is conversant with the ConnREAP™ procedure, including the business case and path to successful commercialization. We want to develop this patent and have it ready for market as soon as possible. We believe that Tom will help us achieve this,” says Mr. Donaldson.

The ConnREAP™ medical device, named for its inventor, Dr. John M. Conn, will be offered worldwide as a 5-piece disposable kit. The device will enable physicians—for the first time—to gain optimal access to the leg arteries and facilitate the best use of catheter and balloon equipment to restore blood flow and prevent amputations.  According to independent studies, this device can substantially increase the rate of limb salvage. Tens of thousands of limbs could be saved annually in just the USA alone.

M. Thomas Boyer, V/P
M. Thomas Boyer, V/P

“I am very appreciative for the chance to join Signet’s effort and bring this innovation to market” said Boyer. “The ConnREAP device resolves a long-standing challenge of accessing blocked vessels below the knee. Dr. Conn’s invention gives surgeons a new tool to save limbs that are being amputated today. For patients suffering from Critical Leg Ischemia or other issues, the ConnREAP device can be THE tool that saves their leg.”

Colorado resident Mr. Boyer is a health care entrepreneur, former board member for a major hospital system, and the former board chair of one of the largest health care foundations in the United States.

“Our goal is to commercialize the ConnREAP device as quickly as possible,” says E. W.  Letiziano, CEO, “the kits must be made available to all surgeons worldwide.  In the past few years, we have experienced an upper trend of amputations over 180,000 in the US; imagine the whole world.  This must stop.  With the proper funding in place, we will drastically reduce this terrible number and make a difference; I hope those with a conscience will contact us. I had no idea this debilitating disease touches so many.”

For additional information contact:

Signet International Holdings, Inc. (OTC: SIGN)
Palm Beach, Florida, USA
1-561-832-2000
http://www.signetinternationalholdings.com 
Email: eletiziano@aol.com   or   info@signetinternationalholdings.com


SIGNET GRAPHENE TECHNOLOGIES, INC.

(a subsidiary of Signet International Holdings, Inc. (OTC: “SIGN”)

Announces the Appointment of Bradley Nelson, Chief Engineer of Project, “deIce 477 ”

Kings Park, NY, February 12, 2019. Tom Donaldson, President, Signet International Holdings, Inc. (SIGN), announced today the appointment of Bradley Nelson, V/P of subsidiary Graphene Technologies, Inc. to assume liaison role in the development of the new deicing project in connection with Florida International University (FIU).

“Brad has the background and credentials, and is very familiar with the FIU Deicing advancement. He will be consulting with Dr. Agarwal, PhD and Chair at FIU. We want to develop this patent to the fullest and have it ready for commercialization as soon as possible; we are confident that Brad will achieve this,” says Mr. Donaldson.

Mr. Nelson has been conducting his research in his lab at Stony Brook University, New York where he has completed the installation of several advanced visualization systems including the “Reality Deck” 1.5 Giga Pixel Display room. He received his Engineering Degree in Aerospace Technology from the State University of New York. He was one of the original designers of the polygon-scanned large screen laser video projection system that was installed at the SAC military facility. While at Ampex Corporation, Mr. Nelson was part of the design team charged with developing the AVA3 computer graphics system and has extensive experience in computer, optical, and electronic engineering including the design and prototyping of multilayer P.C. boards. Mr. Nelson has been granted several U.S Patents. He also developed stereoscopic displays used by Intel, NVidia, Kia, Hewlett Packard, Sony, and the Jet Propulsion Laboratories. He joined SIGN in March 2007.

“I am pleased Brad accepted our offer to head-up this project; his enthusiasm encourages us even more,” says Mr. Ernest Letiziano, CEO, SIGN. “We worked on several projects in the past 12 years. This time, I have to admit, I have never seen Brad so motivated. After all, we call it “deIce 477” because its 477% more efficient. The airlines and especially the travelers will be happy about that. As our strong relationship with our friends at FIU continues to grow, Brad will keep us focused on this and many more FIU projects to come.”

“I am thrilled to accept this appointment to oversee the development of this exciting cutting edge technology,” says Mr. Nelson. Graphene as described in Wikipedia is the basic structural element for carbon nanotubes and other related allotropes of carbon. The hexagonal structure is the strongest material ever tested and the work in this field has resulted in two Nobel Prizes in Physics, “for groundbreaking experiments regarding the two-dimensional material graphene.”

“The potential for developing applications and products for graphene are limitless, in the near future graphene will be everywhere,” Mr. Nelson continued. “Getting in on the ground floor of this revolution of new technology is a dream come true for me. I have found working with Ernie on various projects over the past 12 years to be a pleasure, his up front and transparent nature regarding business operations make for a supportive work environment maintaining critical open communication.”

SIGN is a public holding company established for the purpose of acquiring unique technology and developing products that make a difference. The company has completed its due diligence and expected to offer its Private Placement Memorandum (PPM) to interested, qualified investors early next month.

For additional information contact:

Signet International Holdings, Inc. (OTC: SIGN)
Palm Beach, Florida, USA
1-561-832-2000
http://www.signetinternationalholdings.com 
Email: eletiziano@aol.com   or   info@signetinternationalholdings.com


SIGNET MEDICAL SOLUTIONS, INC.

(A Subsidiary of Signet International Holdings, Inc. OTC: SIGN)

ANNOUNCES ACQUISITION OF A NEW MEDICAL DEVICE TO PREVENT AMPUTATIONS

Colorado Springs, CO   January 23, 2019. Signet’s Board of Directors voted unanimously to purchase all rights and title to a revolutionary medical device from POLR Angioscience, LLC.  The device, which will be offered worldwide as a 5-piece disposable kit, will enable physicians—for the first time—to gain optimal access to the leg arteries and facilitate the best use of catheter and balloon equipment to restore blood flow and prevent amputations.  According to independent studies, this device will substantially increase the rate of limb salvage. Tens of thousands of limbs could be saved per year in the USA alone.

Signet-Conn-John-CSSA
Inventor, Dr. John M.Conn

“We have trademarked our device ConnREAP,” says Mr. Ernest Letiziano, CEO of Signet. “Its inventor, Dr. John Conn, is a vascular surgeon trained at Emory University. He has utilized the device to successfully, consistently overcome severe challenges in reaching and correcting complex blockages in the leg arteries.”

The pain and disability caused by narrowed leg arteries often ends tragically in amputation, and the technical difficulties conquered by the device allow more surgeons to restore effective blood flow.  A huge and growing vulnerable population is at risk for limb loss because of aging, diabetes, and hypertension. They can benefit by this device which simplifies access to correcting the root cause: the bulky yellowish build-up of plaque in arteries.

A multinational independent research clinic spent more than a year investigating and reporting on the device.  The results were positive and encouraging, with the recommendation to proceed with development.  The device is FDA classified as a trocar, and the procedures for which it is used are covered by Medicare and health insurers.

Mr. Tom Donaldson, President of Signet, expressed his gratitude to Dr. Conn and offered staggering statistics.  “Our research shows that here in the USA alone we average over 180,000 amputations per year, and all indications are that we may expect more.  We know that the mortality rate is well over 50% after one year, not merely from surgery but from the medical results of impaired function.  The emotional anguish suffered by these patients is enormous,” says Donaldson. Dr. Conn, who has devoted many years to preventing amputations, noted, “I am very pleased to see this promising device taken to the next level by the Signet team.”

Signet’s Board is determined to make the ConnREAP™ device available to every surgeon in the world by mid-next year. “This is a debilitating disease,” says Mr. Letiziano. “There is no doubt that our ConnREAP™ device will alter the lives of those who are being tormented with making such a frightful decision as amputation. This device will make a difference. We are close to our final design stage and a successful funding offering. Our goal is to start manufacturing and offering the kit for delivery quickly and have patients dancing again. Our stock offering is published and investors are welcome to join us in a meaningful endeavor.”

For additional information contact:

Signet International Holdings, Inc. (OTC: SIGN)
Palm Beach, Florida, USA
1-561-832-2000
http://www.signetinternationalholdings.com 
Email: eletiziano@aol.com   or   info@signetinternationalholdings.com


Forward Looking Safe Harbor Statement: This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. By their nature, forward-looking statements and forecasts involve risks and uncertainties because they relate to events and depend on circumstances that will occur in the near future. There are a number of factors that could cause actual results and developments to differ materially from forecasted results. These risks and uncertainties include product demand, market competition, delays in website development, and risks inherent in our operations. For a discussion of these risks and uncertainties, please see our filings with the Securities and Exchange Commission. Our public filings with the SEC are available from commercial document retrieval services and at the website http://www.sec.gov


Signet Graphene Technologies, Inc.

(a Subsidiary of Signet international Holdings, Inc., OTC: SIGN)
Signs Agreement with Florida International University (FIU)

GRAPHENE TECHNOLOGY TO DEICE AIRCRAFT ENTERS $1.30 BILLION DEICING MARKET,
TIME-SAVING, MORE EFFICIENT & LESS TOXIC WASTE [1]

Miami, Florida January 15, 2019   Mr. Tom Donaldson, President, Signet International Holdings, Inc. (OTC: SIGN), the parent company of Signet Graphene Technologies, Inc. (SGT), announced today that the company has executed a contract with Florida International University (FIU) to further the development and commercialization of a new deicing technology enhanced by graphene, the revolutionary carbon-based nanotechnology.

Adhesion of ice to the surfaces of aircraft in inclement weather severely compromises aircraft aerodynamic performance. Time-consuming airport deicing operations are performed for safety, causing extensive flight delays for travelers and a heavy financial burden for the airline industry. Airport Lifestyle magazine notes that the average cost of deicing a passenger aircraft is over $7,000 per coating.

deiceingpic3
Icy conditions can severely compromise aircraft aerodynamic performance.

A team of engineers at Florida International University headed up by Professor Arvind Agarwal, PhD, Chair of Mechanical and Materials Engineering and his team in Plasma Forming Laboratory: Ms Jenniffer Bustillos, Dr. Cheng Zhang and Dr. Benjamin Boesl have developed a graphene foam−polymer composite with superior deicing efficiency and strength. (Patent issue Jan. 22, 2019)    

The graphene-foam polymer composite provides lightweight coatings and free-standing components with heating abilities, with exceptional thermal stability. The graphene reinforcement also increases the tensile strength of the polymer coating on the aircraft and reduces the impact of nasty toxic chemical runoff seeping into the ground and water.

The patent application, entitled, “Three Dimensional Graphene Foam Reinforced Composite Coating & Deicing Systems Therefrom,” was a result of research conducted by a grant from the U.S. Army Research Office. Signet Graphene Technologies, Inc., intends to further develop the technology and make it ready for mass production. This invention is expected to have a major impact on the aircraft deicing market, which, according to Opus Materials Technologies, the U.S. spends over $1.30 billion in deicing fluids alone.

“This contract marks the first of an exciting ongoing relationship with FIU,” says Donaldson. “This invention is the solution to a very practical problem in air transportation. Critically low temperature conditions are the reasons delays are imminent, costing the airlines and travelers time and money. Although our focus is on time and safety in the airline industry, we are discovering an abundance of uses for this technology. In fact, we are exploring applied applications in solving icing conditions from icy steps; turbine blades and their mechanics, helicopter rotor blades; even private home uses and other subzero problems.”

“It is a pleasure to be associated with FIU,” says Ernest Letiziano, CEO, SIGN. “We were looking for applied use of graphene that can be made available to the public quickly; this invention is the answer to efficiency and toxic waste. The Army Grant technology has been achieved; we will take it from here.”

SIGN is currently preparing a Private Placement Memorandum (PPM) to be published shortly. The company welcomes interested investors to contact the Palm Beach office to learn more.

For additional information contact:

Signet International Holdings, Inc. (OTC: SIGN)
Palm Beach, Florida, USA
1-561-832-2000
http://www.signetinternationalholdings.com 
Email: eletiziano@aol.com   or   info@signetinternationalholdings.com


Forward Looking Safe Harbor Statement: This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. By their nature, forward-looking statements and forecasts involve risks and uncertainties because they relate to events and depend on circumstances that will occur in the near future. There are a number of factors that could cause actual results and developments to differ materially from forecasted results. These risks and uncertainties include product demand, market competition, delays in website development, and risks inherent in our operations. For a discussion of these risks and uncertainties, please see our filings with the Securities and Exchange Commission. Our public filings with the SEC are available from commercial document retrieval services and at the website http://www.sec.gov

[1] ACS Publications  2018


January 4, 2019 …Palm Beach, Florida

NEW GRAPHENE INNOVATION CENTER OPENS IN ENGLAND

The Graphene Innovation center, a £60 million world-class center dedicated to researching graphene and its applications has been opened in Manchester.

The Graphene Engineering Innovation Center (GEIC) at the University of Manchester will accelerate the commercial impact of graphene and help realize its potential to revolutionize many sectors.The center received £15 million funding through UKRI’s Research England UK Research Partnership Investment Fund (UKRPIF) in 2014, and £5 million from UKRI’s Innovate UK.Read the full article here: Graphene Info

For additional information on graphene-based technology contact:

Signet International Holdings, Inc. (OTC: SIGN)
Palm Beach, Florida, USA
1-561-832-2000
http://www.signetinternationalholdings.com 
Email: eletiziano@aol.com   or   info@signetinternationalholdings.com

__________________________________________________

MARKET FOR GRAPHENE BATTERIES PREDICTED TO REACH $115 MILLION

Palm Beach, FL, October 12, 2018

As the need for clean, reliable energy continues to grow and expand, the market for clean energy produced with graphene batteries continues to improve. Graphene is a carbon-based material that may be the best heat and electricity conducting material ever discovered.

We can eliminate society’s carbon footprint by finding uses for carbon that are so valuable it makes no sense to waste it out of our smokestacks, turbines, or tailpipes. In this regard, graphene has the potential to offer clean energy now, in the near future, and for future generations to come. Imagine a strong, light, widely available material that can conduct electricity with greatly reduced energy loss. On small or large grids, graphene will revolutionize production and distribution of energy from power plants to cell phones.

Graphene is the perfect conductor—it offers relatively little resistance to electrons, carries electricity better than even superb conductors such as copper. Unlike superconductors that need to be cooled to low temperatures to function, graphene’s remarkable conductivity works at room temperature.

By 2022, the market for graphene batteries is predicted to reach $115 million. The potential beyond that as the technology grows and improves, is one of the main more and more companies worldwide have attracted significant interest in the development of graphene-based energy.  The time for investing in graphene batteries is now.

Feature article in Wired:

A Graphene Breakthrough Hints at the Future of Battery Power

https://www.wired.co.uk/article/graphene-batteries-supercapacitors

For additional information on graphene-based technology contact:

Signet International Holdings, Inc. (OTC: SIGN)
Palm Beach, Florida, USA
1-561-832-2000
http://www.signetinternationalholdings.com 
Email: eletiziano@aol.com   or   info@signetinternationalholdings.com


GRAPHENE ON THE CUSP OF REVOLUTIONIZING ENERGY STORAGE

Palm Beach, FL, August 29, 2018

Graphene, nicknamed the “wonder material” for its unlimited amount of potential applications, is on the cusp of revolutionizing energy and energy storage. Eco-friendly and sustainable, graphene is extremely lightweight, chemically inert, and is a potent conductor of electrical and thermal energy.

That the wonder material is making a resurgence, at least in the eyes of investors, is not surprising. Years of R&D have shown enormous possibility that graphene-based battery powered technology has in store for the field of energy storage.

Graphene enhances and improves conventional battery electrode materials significantly. Batteries made of graphene are lighter, more durable, improves energy density and heightens capacity to provide far greater energy storage, and thus extend the battery’s life span. Graphene also adds conductivity without the amounts of carbon found in conventional batteries.

For additional information on graphene-based technology contact:

Signet International Holdings, Inc. (OTC: SIGN)
Palm Beach, Florida, USA
1-561-832-2000
http://www.signetinternationalholdings.com 
Email: eletiziano@aol.com   or   info@signetinternationalholdings.com

Read about graphene’s impact on the energy sector:

https://www.bloomberg.com/news/articles/2018-04-10/once-hot-material-graphene-could-be-next-battery-breakthrough